A novel knockout mouse model of the noncoding antisense Brain-Derived Neurotrophic Factor (Bdnf) gene displays increased endogenous Bdnf protein and improved memory function following exercise

A novel knockout mouse model of the noncoding antisense Brain-Derived Neurotrophic Factor (Bdnf) gene displays increased endogenous Bdnf protein and improved memory function following exercise

Brain-derived neurotrophic factor (Bdnf) expression is tightly controlled at the transcriptional and post-transcriptional levels. Previously, we showed that inhibition of noncoding Bdnf antisense (Bdnf-AS) RNA upregulates Bdnf protein. Here, we generated a Bdnf-antisense knockout (Bdnf-AS KO) mouse...

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Bibliographic Details
Main Authors: Farzaneh Modarresi, Roya Pedram Fatemi, Seyedeh Fatemeh Razavipour, Natalie Ricciardi, Madina Makhmutova, Nathalie Khoury, Marco Magistri, Claude-Henry Volmar, Claes Wahlestedt, Mohammad Ali Faghihi
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Heliyon
Subjects:
Knockout mouse
BDNF
Exercise
Learning
Memory
Antisense RNA
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402101673X

Internet

http://www.sciencedirect.com/science/article/pii/S240584402101673X

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