Synthesis, Characterization, and In Vitro and In Vivo Evaluations of 4-(N)-Docosahexaenoyl 2′, 2′-Difluorodeoxycytidine with Potent and Broad-Spectrum Antitumor Activity

Synthesis, Characterization, and In Vitro and In Vivo Evaluations of 4-(N)-Docosahexaenoyl 2′, 2′-Difluorodeoxycytidine with Potent and Broad-Spectrum Antitumor Activity

In this study, a new compound, 4-(N)-docosahexaenoyl 2′, 2′-difluorodeoxycytidine (DHA-dFdC), was synthesized and characterized. Its antitumor activity was evaluated in cell culture and in mouse models of pancreatic cancer. DHA-dFdC is a poorly soluble, pale yellow waxy solid, with a molecular mass...

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Bibliographic Details
Main Authors: Youssef W. Naguib, Dharmika Lansakara-P., Laura M. Lashinger, B. Leticia Rodriguez, Solange Valdes, Mengmeng Niu, Abdulaziz M. Aldayel, Lan Peng, Stephen D. Hursting, Zhengrong Cui
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558615001578

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http://www.sciencedirect.com/science/article/pii/S1476558615001578

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