Genomic Profiling of Circulating Tumor DNA Predicts Outcome and Demonstrates Tumor Evolution in ALK-Positive Non-Small Cell Lung Cancer Patients

Genomic Profiling of Circulating Tumor DNA Predicts Outcome and Demonstrates Tumor Evolution in ALK-Positive Non-Small Cell Lung Cancer Patients

With the rapid development of targeted therapies for the treatment of cancer, methods for predicting response and outcome are in high demand. Non-small cell lung cancer driven by genomic rearrangements of the anaplastic lymphoma kinase (<i>ALK</i>) gene can be successfully treated with A...

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Bibliographic Details
Main Authors: Anne Tranberg Madsen, Anne Winther-Larsen, Tine McCulloch, Peter Meldgaard, Boe Sandahl Sorensen
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
serial monitoring
next-generation sequencing
ALK tyrosine kinase receptor
cell-free DNA
circulating tumor DNA
targeted therapy
Online Access:https://www.mdpi.com/2072-6694/12/4/947

Internet

https://www.mdpi.com/2072-6694/12/4/947

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