Zika Virus-Immune Plasmas from Symptomatic and Asymptomatic Individuals Enhance Zika Pathogenesis in Adult and Pregnant Mice

Zika Virus-Immune Plasmas from Symptomatic and Asymptomatic Individuals Enhance Zika Pathogenesis in Adult and Pregnant Mice

Antibody-dependent enhancement (ADE) of virus infection is common to many viruses and is problematic when plasma antibody levels decline to subneutralizing concentrations. ADE of infection is especially important among flaviviruses, many of which are the cause of global health problems. Recently, hu...

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Bibliographic Details
Main Authors: Byoung-Shik Shim, Young-Chan Kwon, Michael J. Ricciardi, Mars Stone, Yuka Otsuka, Fatma Berri, Jaclyn M. Kwal, Diogo M. Magnani, Cody B. Jackson, Audrey S. Richard, Philip Norris, Michael Busch, Christine L. Curry, Michael Farzan, David Watkins, Hyeryun Choe
Format: Article
Language:English
Published: American Society for Microbiology 2019-07-01
Series:mBio
Subjects:
zika virus
antibody-dependent enhancement
congenital disease
homotypic
microcephaly
pregnancy
vaccine
viral pathogenesis
Online Access:https://doi.org/10.1128/mBio.00758-19

Internet

https://doi.org/10.1128/mBio.00758-19

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