Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's Disease: a cross-sectional study

<p>Abstract</p> <p>Background</p> <p>The presence of the apolipoprotein E (APOE) ε4 allele is a major risk factor for the development of Alzheimer's disease (AD), and has been associated with metabolic brain changes several years before the onset of typical AD symp...

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Bibliographic Details
Main Authors: Torgerson Britta M, Ries Michele L, Schmitz Taylor W, Trivedi Mehul A, Sager Mark A, Hermann Bruce P, Asthana Sanjay, Johnson Sterling C
Format: Article
Language:English
Published: BMC 2006-01-01
Series:BMC Medicine
Online Access:http://www.biomedcentral.com/1741-7015/4/1