The inhibitory receptor Tim-3 fails to suppress IFN-γ production via the NFAT pathway in NK-cell, unlike that in CD4+ T cells

The inhibitory receptor Tim-3 fails to suppress IFN-γ production via the NFAT pathway in NK-cell, unlike that in CD4+ T cells

Abstract Background T cell immunoglobulin and mucin domain-containing-3 (Tim-3) is a negative regulator expressed on T cells, and is also expressed on natural killer (NK) cells. The function of Tim-3 chiefly restricts IFNγ-production in T cells, however, the impact of Tim-3 on NK cell function has n...

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Bibliographic Details
Main Authors: Xiaowen Yu, Bin Lang, Xi Chen, Yao Tian, Shi Qian, Zining Zhang, Yajing Fu, Junjie Xu, Xiaoxu Han, Haibo Ding, Yongjun Jiang
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Immunology
Subjects:
Tim-3
IFN-γ
NK cells
NFAT
HIV infection
Online Access:https://doi.org/10.1186/s12865-021-00417-9

Internet

https://doi.org/10.1186/s12865-021-00417-9

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