Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations

Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations

Rett syndrome (RTT) is an X chromosome-linked neurodevelopmental disorder associated with the characteristic neuropathology of dendritic spines common in diseases presenting with mental retardation (MR). Here, we present the first quantitative analyses of dendritic spine density in postmortem brain...

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Bibliographic Details
Main Authors: Christopher A. Chapleau, Gaston D. Calfa, Meredith C. Lane, Asher J. Albertson, Jennifer L. Larimore, Shinichi Kudo, Dawna L. Armstrong, Alan K. Percy, Lucas Pozzo-Miller
Format: Article
Language:English
Published: Elsevier 2009-08-01
Series:Neurobiology of Disease
Subjects:
MeCP2
Rett syndrome
Dendrite
Dendritic spine
Pyramidal neuron
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000990

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http://www.sciencedirect.com/science/article/pii/S0969996109000990

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