Structural modeling of tissue-specific mitochondrial alanyl-tRNA synthetase (AARS2) defects predicts differential effects on aminoacylation

Structural modeling of tissue-specific mitochondrial alanyl-tRNA synthetase (AARS2) defects predicts differential effects on aminoacylation

The accuracy of mitochondrial protein synthesis is dependent on the coordinated action of nuclear-encoded mitochondrial aminoacyl-tRNA synthetases (mtARSs) and the mitochondrial DNA-encoded tRNAs. The recent advances in whole-exome sequencing have revealed the importance of the mtARS proteins for mi...

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Bibliographic Details
Main Authors: Liliya eEuro, Svetlana eKonovalova, Jorge eAsin Cayuela, Már eTulinius, Helen eGriffin, Rita eHorvath, Robert W Taylor, Patrick F Chinnery, Ulrike eSchara, David R Thorburn, Anu eSuomalainen, Joseph eChihade, Henna eTyynismaa
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Genetics
Subjects:
Structural modeling
mitochondrial disease
tissue-specificity
aminoacyl-tRNA synthetases
Alanyl-tRNA synthetase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00021/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00021/full

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