Involvement of GluA1-AMPAR-mediated LTP in time-dependent decline of cognitive function in rats with temporal lobe epilepsy

Involvement of GluA1-AMPAR-mediated LTP in time-dependent decline of cognitive function in rats with temporal lobe epilepsy

Abstract Background Cognitive impairment is one of the common comorbidities in patients with temporal lobe epilepsy (TLE), but the underlying mechanisms remain largely unknown. Previous studies have found significant decay of hippocampal long-term potentiation (LTP) in TLE rats with cognitive impair...

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Bibliographic Details
Main Authors: Xiaoqing Luo, Xiaoli Yu, Jufang Liang, Ruidi Sun, Cheng Li, Jun Jiang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Acta Epileptologica
Subjects:
Cognitive impairment
Temporal lobe epilepsy
Long-term potentiation
Hippocampus
AMPA receptor
Online Access:https://doi.org/10.1186/s42494-020-00036-8

Internet

https://doi.org/10.1186/s42494-020-00036-8

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