Synthetic Studies on Erythromycin Derivatives: Reactivity of the C12-21 Alkene

The reactivity of the C12-21 alkene of some erythromycin A derivatives was studied. This double bond was easily oxidized to the corresponding epoxide with excellent stereoselectivity. A single crystal X-ray structure showed that the epoxide moiety was on the same side as the acetonide. When an eryth...

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Bibliographic Details
Main Author: Wei-Min Chen
Format: Article
Language:English
Published: MDPI AG 2006-01-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/11/1/121/