Reactivation of heat-inactivated Ku proteins by heat shock cognate protein HSC73

Purpose: Mouse double-stranded DNA-dependent protein kinase (DNA-PK) activity is heat sensitive. Recovery of heat-inactivated DNA repair activity is a problem after combination therapy with radiation and heat. We investigated the mechanism of recovery of heat-inactivated DNA-PK activity. Methods: Hy...

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Bibliographic Details
Main Authors: Makoto Ihara, Kazuko Shichijo, Takashi Kudo, Kenzo Ohtsuka
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:International Journal of Hyperthermia
Subjects:
Online Access:http://dx.doi.org/10.1080/02656736.2019.1587009