Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis

Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis

Abstract Background In human immunodeficiency virus-1 (HIV-1) infection, activation of astrocytes induces imbalance in physiological functions due to perturbed astrocytic functions that unleashes toxicity on neurons. This leads to inflammatory response finally culminating into neurocognitive dysfunc...

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Bibliographic Details
Main Authors: Priyanka, Renu Wadhwa, Rituparna Chaudhuri, Tapas Chandra Nag, Pankaj Seth
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Neuroinflammation
Subjects:
Astrocytes
Glia
HIV-1 Tat
Mortalin
Neuroinflammation
Neuronal survival
Online Access:http://link.springer.com/article/10.1186/s12974-020-01912-3

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http://link.springer.com/article/10.1186/s12974-020-01912-3

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