Chloroquine inhibits Ca2+ permeable ion channels-mediated Ca2+ signaling in primary B lymphocytes

Chloroquine inhibits Ca2+ permeable ion channels-mediated Ca2+ signaling in primary B lymphocytes

Abstract Background Chloroquine, a bitter tastant, inhibits Ca2+ signaling, resulting in suppression of B cell activation; however, the inhibitory mechanism remains unclear. Results In this study, thapsigargin (TG), but not caffeine, induced sustained intracellular Ca2+ increases in mouse splenic pr...

Full description

Bibliographic Details
Main Authors: Yi-Fan Wu, Ping Zhao, Xi Luo, Jin-Chao Xu, Lu Xue, Qi Zhou, Mingrui Xiong, Jinhua Shen, Yong-Bo Peng, Meng-Fei Yu, Weiwei Chen, Liqun Ma, Qing-Hua Liu
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Cell & Bioscience
Subjects:
B cells
Ca2+
Chloroquine
IP3R
TRPC3 channels
STIM/Orai channels
Online Access:http://link.springer.com/article/10.1186/s13578-017-0155-5

Internet

http://link.springer.com/article/10.1186/s13578-017-0155-5

Similar Items