Cigarette smoke enhances oncogene addiction to c‐MET and desensitizes EGFR‐expressing non‐small cell lung cancer to EGFR TKIs

Cigarette smoke enhances oncogene addiction to c‐MET and desensitizes EGFR‐expressing non‐small cell lung cancer to EGFR TKIs

Cigarette smoking is one of the leading risks for lung cancer and is associated with the insensitivity of non‐small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, it remains undetermined whether and how cigarette smoke affects the ther...

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Bibliographic Details
Main Authors: Chih‐Yen Tu, Fang‐Ju Cheng, Chuan‐Mu Chen, Shu‐Ling Wang, Yu‐Chun Hsiao, Chia‐Hung Chen, Te‐Chun Hsia, Yu‐Hao He, Bo‐Wei Wang, I‐Shan Hsieh, Yi‐Lun Yeh, Chih‐Hsin Tang, Yun‐Ju Chen, Wei‐Chien Huang
Format: Article
Language:English
Published: Wiley 2018-05-01
Series:Molecular Oncology
Subjects:
benzo[α]pyrene
cigarette smoke
c‐MET
EGFR‐TKI
lung cancer
Online Access:https://doi.org/10.1002/1878-0261.12193

Internet

https://doi.org/10.1002/1878-0261.12193

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