One-Pot Synthesis of Novel Chiral β-Amino Acid Derivatives by Enantioselective Mannich Reactions Catalyzed by Squaramide Cinchona Alkaloids

One-Pot Synthesis of Novel Chiral β-Amino Acid Derivatives by Enantioselective Mannich Reactions Catalyzed by Squaramide Cinchona Alkaloids

An efficient one-pot synthesis of novel β-amino acid derivatives containing a thiadiazole moiety was developed using a chiral squaramide cinchona alkaloid as organocatalyst. The reactions afforded chiral β-amino acid derivatives in moderate yields and with moderate to excellent enantioselectivities....

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Bibliographic Details
Main Authors: Kankan Zhang, Xueping Liang, Ming He, Jian Wu, Yuping Zhang, Wei Xue, Linhong Jin, Song Yang, Deyu Hu
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Molecules
Subjects:
Asymmetric Mannich addition
β-amino acid derivatives
1,3,4-thiadiazole moiety
thiourea derived from squaramide cinchona alkaloid
Online Access:http://www.mdpi.com/1420-3049/18/6/6142

Internet

http://www.mdpi.com/1420-3049/18/6/6142

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