Effect of pre-analytic variables on the reproducibility of qPCR relative telomere length measurement.

Effect of pre-analytic variables on the reproducibility of qPCR relative telomere length measurement.

Telomeres, long nucleotide repeats and a protein complex at chromosome ends, shorten with each cell division and are susceptible to oxidative damage. Quantitative PCR (qPCR) is a widely-used technique to measure relative telomere length (RTL) in DNA samples but is challenging to optimize and signifi...

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Bibliographic Details
Main Authors: Casey L Dagnall, Belynda Hicks, Kedest Teshome, Amy A Hutchinson, Shahinaz M Gadalla, Payal P Khincha, Meredith Yeager, Sharon A Savage
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5590866?pdf=render

Internet

http://europepmc.org/articles/PMC5590866?pdf=render

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