Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo

Quiescent long-term hematopoietic stem cells (LT-HSCs) are efficiently activated by type I interferon (IFN-I). However, this effect remains poorly investigated in the context of IFN-I-inducing virus infections. Here we report that both vesicular stomatitis virus (VSV) and murine cytomegalovirus (MCM...

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Bibliographic Details
Main Authors: Christoph Hirche, Theresa Frenz, Simon F. Haas, Marius Döring, Katharina Borst, Pia-K. Tegtmeyer, Ilija Brizic, Stefan Jordan, Kirsten Keyser, Chintan Chhatbar, Eline Pronk, Shuiping Lin, Martin Messerle, Stipan Jonjic, Christine S. Falk, Andreas Trumpp, Marieke A.G. Essers, Ulrich Kalinke
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
hematopoietic stem cells
quiescence
cell cycle
stem cell activation
systemic inflammation
inflammatory cytokines
virus infections
stem cell function
bone marrow transplantation
transplant complications
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717307209

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http://www.sciencedirect.com/science/article/pii/S2211124717307209

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