Remodeling of striatal NMDA receptors by chronic A2A receptor blockade in Huntington's disease mice

Remodeling of striatal NMDA receptors by chronic A2A receptor blockade in Huntington's disease mice

Excitotoxicity plays a major role in the pathogenesis of Huntington disease (HD), a fatal neurodegenerative disorder. Adenosine A2A receptors (A2ARs) modulate excitotoxicity and have been suggested to play a pathogenetic role in HD. The main aim of this study was to evaluate the effect of A2AR block...

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Bibliographic Details
Main Authors: Alberto Martire, Antonella Ferrante, Rosa Luisa Potenza, Monica Armida, Roberta Ferretti, Antonella Pézzola, Maria Rosaria Domenici, Patrizia Popoli
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Neurobiology of Disease
Subjects:
Huntington disease
Adenosine A2A receptor
NMDA receptor subunit
BDNF
R6/2 mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002642

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http://www.sciencedirect.com/science/article/pii/S0969996109002642

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