Maternal and fetal mechanisms of B cell regulation during pregnancy: human Chorionic Gonadotropin stimulates B cells to produce IL-10 while alpha-fetoprotein drives them into apoptosis

Maternal and fetal mechanisms of B cell regulation during pregnancy: human Chorionic Gonadotropin stimulates B cells to produce IL-10 while alpha-fetoprotein drives them into apoptosis

Maternal immune tolerance towards the fetus is an essential requisite for pregnancy. While T cell functions are well documented, little is known about the participation of B cells. We have previously suggested that IL-10 producing B cells are involved in pregnancy tolerance in mice and humans. By em...

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Bibliographic Details
Main Authors: Franziska Fettke, Anne Schumacher, Andrea Canellada, Natalia Toledo, Isabelle Bekeredjian-Ding, Albert Bondt, Manfred Wuhrer, Serban Dan Costa, Ana Claudia Zenclussen
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Immunology
Subjects:
Hormones
Placenta
Pregnancy
tolerance
IL-10
B cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00495/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00495/full

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