Periostin Limits Tumor Response to VEGFA Inhibition

Periostin Limits Tumor Response to VEGFA Inhibition

Summary: Resistance to antiangiogenic drugs limits their applicability in cancer therapy. Here, we show that revascularization and progression of pancreatic neuroendocrine tumors (PNETs) under extended vascular-endothelial growth factor A (VEGFA) blockade are dependent on periostin (POSTN), a matric...

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Bibliographic Details
Main Authors: Ioanna Keklikoglou, Ece Kadioglu, Stefan Bissinger, Benoît Langlois, Axel Bellotti, Gertraud Orend, Carola H. Ries, Michele De Palma
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471830216X

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http://www.sciencedirect.com/science/article/pii/S221112471830216X

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