Celsr3 is required for Purkinje cell maturation and regulates cerebellar postsynaptic plasticity

Celsr3 is required for Purkinje cell maturation and regulates cerebellar postsynaptic plasticity

Summary: Atypical cadherin Celsr3 is critical for brain embryonic development, and its role in the postnatal cerebellum remains unknown. Using Celsr3-GFP mice, Celsr3 shows high expression in postnatal Purkinje cells (PCs). Mice with conditional knockout (cKO) of Celsr3 in postnatal PCs exhibit defi...

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Bibliographic Details
Main Authors: Qinji Zhou, Jingwen Qin, Yaying Liang, Wei Zhang, Siyuan He, Fadel Tissir, Yibo Qu, Libing Zhou
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:iScience
Subjects:
Developmental neuroscience
Cognitive neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422100780X

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http://www.sciencedirect.com/science/article/pii/S258900422100780X

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