Amino Acids Attenuate Insulin Action on Gluconeogenesis and Promote Fatty Acid Biosynthesis via mTORC1 Signaling Pathway in trout Hepatocytes

Amino Acids Attenuate Insulin Action on Gluconeogenesis and Promote Fatty Acid Biosynthesis via mTORC1 Signaling Pathway in trout Hepatocytes

Background/Aims: Carnivores exhibit poor utilization of dietary carbohydrates and glucose intolerant phenotypes, yet it remains unclear what are the causal factors and underlying mechanisms. We aimed to evaluate excessive amino acids (AAs)-induced effects on insulin signaling, fatty acid biosynthesi...

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Bibliographic Details
Main Authors: Weiwei Dai, Stéphane Panserat, Elisabeth Plagnes-Juan, Iban Seiliez, Sandrine Skiba-Cassy
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
mTORC1
Insulin action
Fatty acid biosynthesis
Gluconeogenesis
Rainbow trout
Amino acids
Online Access:http://www.karger.com/Article/FullText/430281

Internet

http://www.karger.com/Article/FullText/430281

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