Strategy to find molecular signatures in a small series of rare cancers: validation for radiation-induced breast and thyroid tumors.
Methods of classification using transcriptome analysis for case-by-case tumor diagnosis could be limited by tumor heterogeneity and masked information in the gene expression profiles, especially as the number of tumors is small. We propose a new strategy, EMts_2PCA, based on: 1) The identification o...
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Public Library of Science (PLoS)