Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA

Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA

Self-amplifying mRNA (saRNA) represents a promising platform for nucleic acid delivery of vaccine immunogens. Unlike plasmid DNA, saRNA does not require entry into the nucleus of target cells for expression, having the capacity to drive higher protein expression compared to mRNA as it replicates wit...

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Bibliographic Details
Main Authors: Yoann Aldon, Paul F. McKay, Jorge Moreno Herrero, Annette B. Vogel, Réka Lévai, Pauline Maisonnasse, Nathalie Dereuddre-Bosquet, Heinrich Haas, Katalin Fábián, Roger Le Grand, Ugur Sahin, Robin J. Shattock
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
saRNA
HIV
Env
vaccine
polyplexes
PEI
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001499

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http://www.sciencedirect.com/science/article/pii/S2162253121001499

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