CypA, a gene downstream of HIF-1α, promotes the development of PDAC.

CypA, a gene downstream of HIF-1α, promotes the development of PDAC.

Hypoxia-inducible factor-1α (HIF-1α) is a highly important transcription factor involved in cell metabolism. HIF-1α promotes glycolysis and inhibits of mitochondrial respiration in pancreatic ductal adenocarcinoma (PDAC). In response to tumor hypoxia, cyclophilin A (CypA) is over-expressed in variou...

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Bibliographic Details
Main Authors: Huan Zhang, Jing Chen, Fenghua Liu, Chuntao Gao, Xiuchao Wang, Tiansuo Zhao, Jingcheng Liu, Song Gao, Xiao Zhao, He Ren, Jihui Hao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3963943?pdf=render

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http://europepmc.org/articles/PMC3963943?pdf=render

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