Stabilization of a Broadly Neutralizing Anti-Chikungunya Virus Single Domain Antibody

Stabilization of a Broadly Neutralizing Anti-Chikungunya Virus Single Domain Antibody

A single domain antibody (clone CC3) previously found to neutralize a vaccine strain of the chikungunya virus (PRNT50 = 2. 5 ng/mL) was found to be broadly neutralizing. Clone CC3 is not only able to neutralize a wild-type (WT) strain of chikungunya virus (CHIKV), but also neutralizes WT strains of...

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Bibliographic Details
Main Authors: Jinny L. Liu, Emily M. Webb, Dan Zabetakis, Crystal W. Burke, Christina L. Gardner, Pamela J. Glass, Patricia M. Legler, James Weger-Lucarelli, George P. Anderson, Ellen R. Goldman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Medicine
Subjects:
chikungunya virus
old world
new world
alphavirus
neutralization
melting temperature
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.626028/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.626028/full

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