Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.

Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.

Spontaneous mutations in the SHANK-associated RH domain interacting protein (Sharpin) resulted in a severe autoinflammatory type of chronic proliferative dermatitis, inflammation in other organs, and lymphoid organ defects. To determine whether cell-type restricted loss of Sharpin causes similar les...

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Bibliographic Details
Main Authors: John P Sundberg, C Herbert Pratt, Leslie P Goodwin, Kathleen A Silva, Victoria E Kennedy, Christopher S Potter, Anisa Dunham, Beth A Sundberg, Harm HogenEsch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0235295

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https://doi.org/10.1371/journal.pone.0235295

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