A new mouse model for marfan syndrome presents phenotypic variability associated with the genetic background and overall levels of Fbn1 expression.

A new mouse model for marfan syndrome presents phenotypic variability associated with the genetic background and overall levels of Fbn1 expression.

Marfan syndrome is an autosomal dominant disease of connective tissue caused by mutations in the fibrillin-1 encoding gene FBN1. Patients present cardiovascular, ocular and skeletal manifestations, and although being fully penetrant, MFS is characterized by a wide clinical variability both within an...

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Bibliographic Details
Main Authors: Bruno L Lima, Enrico J C Santos, Gustavo R Fernandes, Christian Merkel, Marco R B Mello, Juliana P A Gomes, Marina Soukoyan, Alexandre Kerkis, Silvia M G Massironi, José A Visintin, Lygia V Pereira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2994728?pdf=render

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http://europepmc.org/articles/PMC2994728?pdf=render

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