Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice

Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice

Proper functioning of the cerebellum is crucial to motor balance and coordination in adult mammals. Purkinje cells (PCs), the sole output neurons of the cerebellar cortex, play essential roles in cerebellar motor function. Tripartite motif-containing protein 32 (TRIM32) is an E3 ubiquitin ligase tha...

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Bibliographic Details
Main Authors: Jian-Wei Zhu, Wei-Qiang Jia, Hui Zhou, Yi-Fei Li, Ming-Ming Zou, Zhao-Tao Wang, Bing-Shan Wu, Ru-Xiang Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
cerebellum
TRIM32
motor coordination (MC)
purkine cell
cerebellar degeneration
INPP5A
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.697494/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.697494/full

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