Ketamine exacerbates cortical neuroapoptosis under hyperoxic conditions by upregulating expression of the N-methyl-D-aspartate receptor subunit NR1 in the developing rat brain

Ketamine exacerbates cortical neuroapoptosis under hyperoxic conditions by upregulating expression of the N-methyl-D-aspartate receptor subunit NR1 in the developing rat brain

Abstract Background Ketamine and hyperoxia are widely used in obstetric and pediatric settings. Either ketamine or hyperoxia has been reported to cause neuroapoptosis in the developing brain, and ketamine-induced neuronal apoptosis may involve a compensatory upregulation of the N-methyl-D-aspartate...

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Bibliographic Details
Main Authors: Changyi Wu, Jun Wang, Xiangyang Guo, Ying Zhang
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Anesthesiology
Subjects:
NMDA receptor antagonist
Ketamine
Hyperoxia
Apoptosis
Newborn
Rat
Online Access:http://link.springer.com/article/10.1186/s12871-018-0511-y

Internet

http://link.springer.com/article/10.1186/s12871-018-0511-y

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