Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages

Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages

Background: Alveolar macrophages (AMs) are resident inflammatory cells in the lung that serve as early sentinels of infection or injury. We have identified thioredoxin reductase 1 inhibition by gold compounds increases activation of nuclear factor erythroid 2-related factor 2 (NRF2)-dependent pathwa...

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Bibliographic Details
Main Authors: Stephanie B. Wall, Rui Li, Brittany Butler, Ashley R. Burg, Hubert M. Tse, Jennifer L. Larson-Casey, A. Brent Carter, Clyde J. Wright, Lynette K. Rogers, Trent E. Tipple
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antioxidants
Subjects:
hyperoxia
auranofin
NFκB
NRF2
Il-1β
Online Access:https://www.mdpi.com/2076-3921/10/5/632

Internet

https://www.mdpi.com/2076-3921/10/5/632

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