Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces.
In this paper we introduce a fully flexible coarse-grained model of immunoglobulin G (IgG) antibodies parametrized directly on cryo-EM data and simulate the binding dynamics of many IgGs to antigens adsorbed on a surface at increasing densities. Moreover, we work out a theoretical model that allows...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-03-01
|
| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC4788199?pdf=render |