Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces.
In this paper we introduce a fully flexible coarse-grained model of immunoglobulin G (IgG) antibodies parametrized directly on cryo-EM data and simulate the binding dynamics of many IgGs to antigens adsorbed on a surface at increasing densities. Moreover, we work out a theoretical model that allows...
Main Authors: | Cristiano De Michele, Paolo De Los Rios, Giuseppe Foffi, Francesco Piazza |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-03-01
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Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC4788199?pdf=render |
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