Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness

Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness

Abstract Background Glioblastoma is the most frequent and high-grade adult malignant central nervous system tumor. The prognosis is still poor despite the use of combined therapy involving maximal surgical resection, radiotherapy, and chemotherapy. Metabolic reprogramming currently is recognized as...

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Bibliographic Details
Main Authors: Yollanda E. Moreira Franco, Maria Jose Alves, Miyuki Uno, Isabele Fattori Moretti, Marina Trombetta-Lima, Suzana de Siqueira Santos, Ancely Ferreira dos Santos, Gabriel Santos Arini, Mauricio S. Baptista, Antonio Marcondes Lerario, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cancer & Metabolism
Subjects:
Glutaminolysis
GBM
Low-grade astrocytoma
IDH1 mutation
Astrocytoma progression
Online Access:https://doi.org/10.1186/s40170-021-00255-8

Internet

https://doi.org/10.1186/s40170-021-00255-8

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