Inhibition of Phosphatidylinositol 3-kinase (PI3K) Signaling Synergistically Potentiates Antitumor Efficacy of Paclitaxel and Overcomes Paclitaxel-Mediated Resistance in Cervical Cancer

Inhibition of Phosphatidylinositol 3-kinase (PI3K) Signaling Synergistically Potentiates Antitumor Efficacy of Paclitaxel and Overcomes Paclitaxel-Mediated Resistance in Cervical Cancer

Acquired paclitaxel (PTX) resistance limits its effectiveness and results in advanced cancer progression. This review investigated whether the inhibition of phosphatidylinositol 3-kinase (PI3K) signaling overcomes paclitaxel resistance in cervical cancer. It was established paclitaxel-resistant cell...

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Bibliographic Details
Main Authors: Jing Jing Liu, Jung Yoon Ho, Hye Won Lee, Min Wha Baik, Oyoung Kim, Youn Jin Choi, Soo Young Hur
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
cervical cancer
combination therapy
paclitaxel resistance
cell cycle
invasion
PI3K inhibitor
Online Access:https://www.mdpi.com/1422-0067/20/14/3383

Internet

https://www.mdpi.com/1422-0067/20/14/3383

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