Phosphorylation of TFCP2L1 by CDK1 is required for stem cell pluripotency and bladder carcinogenesis

Phosphorylation of TFCP2L1 by CDK1 is required for stem cell pluripotency and bladder carcinogenesis

Abstract Molecular programs involved in embryogenesis are frequently upregulated in oncogenic dedifferentiation and metastasis. However, their precise roles and regulatory mechanisms remain elusive. Here, we showed that CDK1 phosphorylation of TFCP2L1, a pluripotency‐associated transcription factor,...

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Bibliographic Details
Main Authors: Jinbeom Heo, Byeong‐Joo Noh, Seungun Lee, Hye‐Yeon Lee, YongHwan Kim, Jisun Lim, Hyein Ju, Hwan Yeul Yu, Chae‐Min Ryu, Peter CW Lee, Hwangkyo Jeong, Yumi Oh, Kyunggon Kim, Sang‐Yeob Kim, Jaekyoung Son, Bumsik Hong, Jong Soo Kim, Yong Mee Cho, Dong‐Myung Shin
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:EMBO Molecular Medicine
Subjects:
bladder cancer
CDK1
embryonic stem cell
pluripotency
stemness features
Online Access:https://doi.org/10.15252/emmm.201910880

Internet

https://doi.org/10.15252/emmm.201910880

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