Small Interference RNA Targeting Connexin-43 Improves Motor Function and Limits Astrogliosis After Juvenile Traumatic Brain Injury

Juvenile traumatic brain injury (jTBI) is the leading cause of death and disability for children and adolescents worldwide, but there are no pharmacological treatments available. Aquaporin 4 (AQP4), an astrocytic perivascular protein, is increased after jTBI, and inhibition of its expression with sm...

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Bibliographic Details
Main Authors: Aleksandra Ichkova, Andrew M. Fukuda, Nina Nishiyama, Germaine Paris, Andre Obenaus, Jerome Badaut
Format: Article
Language:English
Published: SAGE Publishing 2019-06-01
Series:ASN Neuro
Online Access:https://doi.org/10.1177/1759091419847090