Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.

Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.

Treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout Africa and Central/South America. Mass drug administration is likely to exert selection pressure on parasites, and phenotypic and genetic changes in several Onchocerca volvulus populati...

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Bibliographic Details
Main Authors: Stephen R Doyle, Catherine Bourguinat, Hugues C Nana-Djeunga, Jonas A Kengne-Ouafo, Sébastien D S Pion, Jean Bopda, Joseph Kamgno, Samuel Wanji, Hua Che, Annette C Kuesel, Martin Walker, Maria-Gloria Basáñez, Daniel A Boakye, Mike Y Osei-Atweneboana, Michel Boussinesq, Roger K Prichard, Warwick N Grant
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5546710?pdf=render

Internet

http://europepmc.org/articles/PMC5546710?pdf=render

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