Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity.

Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity.

Interleukin 1 Receptor antagonist (IL-1Ra) is highly elevated in obesity and is widely recognized as an anti-inflammatory cytokine. While the anti-inflammatory role of IL-1Ra in the pancreas is well established, the role of IL-1Ra in other insulin target tissues and the contribution of systemic IL-1...

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Bibliographic Details
Main Authors: Niclas Franck, Michael Maris, Sarah Nalbandian, Saswata Talukdar, Simon Schenk, Hans-Peter Hofmann, David Bullough, Olivia Osborn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4171490?pdf=render

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http://europepmc.org/articles/PMC4171490?pdf=render

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