Detection of low-level HCV variants in DAA treated patients: comparison amongst three different NGS data analysis protocols

Detection of low-level HCV variants in DAA treated patients: comparison amongst three different NGS data analysis protocols

Abstract Background Notwithstanding the efforts of direct-acting antivirals (DAAs) for the treatment of chronically infected hepatitis C virus (HCV) patients, concerns exist regarding the emergence of resistance-associated substitutions (RAS) related to therapy failure. Sanger sequencing is still th...

Full description

Bibliographic Details
Main Authors: Valeria Caputo, Roberta Antonia Diotti, Enzo Boeri, Hamid Hasson, Michela Sampaolo, Elena Criscuolo, Sabrina Bagaglio, Emanuela Messina, Caterina Uberti-Foppa, Matteo Castelli, Roberto Burioni, Nicasio Mancini, Massimo Clementi, Nicola Clementi
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Virology Journal
Subjects:
HCV
DAA failure
RAS detection
NGS
Online Access:http://link.springer.com/article/10.1186/s12985-020-01381-3

Internet

http://link.springer.com/article/10.1186/s12985-020-01381-3

Similar Items