AT2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating BDNF expression

AT2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating BDNF expression

It is widely accepted that the angiotensin AT2-receptor (AT2R) has neuroprotective features. In the present study we tested pharmacological AT2R-stimulation as a therapeutic approach in a model of spinal cord compression injury (SCI) in mice using the novel non-peptide AT2R-agonist, Compound 21 (C21...

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Bibliographic Details
Main Authors: Pawel Namsolleck, Francesco Boato, Katja Schwengel, Ludovit Paulis, Katherine S. Matho, Nathalie Geurts, Christa Thöne-Reineke, Kristin Lucht, Kerstin Seidel, Anders Hallberg, Björn Dahlöf, Thomas Unger, Sven Hendrix, U. Muscha Steckelings
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Neurobiology of Disease
Subjects:
Angiotensin
AT2-receptor
Spinal cord injury
New therapies
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003713

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http://www.sciencedirect.com/science/article/pii/S0969996112003713

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