Inhibitory effects of iron depletion plus eribulin on the breast cancer microenvironment

Inhibitory effects of iron depletion plus eribulin on the breast cancer microenvironment

Abstract Background Iron is required for the proliferation of cancer cells, and its depletion suppresses tumor growth. Eribulin mesylate (eribulin), a non-taxane microtubule inhibitor, disrupts the tumor microenvironment via vascular remodeling and obstruction of the epithelial-mesenchymal transitio...

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Bibliographic Details
Main Authors: Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Tamami Morisaki, Katsuyuki Takahashi, Hisakazu Fujita, Masatsune Shibutani, Ryosuke Amano, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa, Masaichi Ohira
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Cancer
Subjects:
Iron chelator
Eribulin mesylate
Breast cancer
Xenograft
Epithelial-mesenchymal transition
Immune checkpoints
Online Access:https://doi.org/10.1186/s12885-020-07673-9

Internet

https://doi.org/10.1186/s12885-020-07673-9

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