Increased Levels of Genomic Instability and Mutations in Homologous Recombination Genes in Locally Advanced Rectal Carcinomas

Increased Levels of Genomic Instability and Mutations in Homologous Recombination Genes in Locally Advanced Rectal Carcinomas

Pre-operative 5-fluoracil-based chemoradiotherapy (nCRT) is the standard treatment for patients with locally advanced rectal cancer (LARC). Patients with pathological complete response (pCR–0% of tumor cells in the surgical specimen after nCRT) have better overall survival and lower risk of recurren...

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Bibliographic Details
Main Authors: Luisa Matos do Canto, Simon J. Larsen, Bruna E. Catin Kupper, Maria Dirlei Ferreira de Souza Begnami, Cristóvam Scapulatempo-Neto, Annabeth Høgh Petersen, Mads M. Aagaard, Jan Baumbach, Samuel Aguiar, Silvia R. Rogatto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Oncology
Subjects:
rectal cancer
DNA copy number changes
neoadjuvant therapy
genomic instability
DNA repair deficiency
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00395/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00395/full

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