Clathrin-Independent Endocytosis Suppresses Cancer Cell Blebbing and Invasion

Clathrin-Independent Endocytosis Suppresses Cancer Cell Blebbing and Invasion

Cellular blebbing, caused by local alterations in cell-surface tension, has been shown to increase the invasiveness of cancer cells. However, the regulatory mechanisms balancing cell-surface dynamics and bleb formation remain elusive. Here, we show that an acute reduction in cell volume activates cl...

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Bibliographic Details
Main Authors: Mikkel Roland Holst, Maite Vidal-Quadras, Elin Larsson, Jie Song, Madlen Hubert, Jeanette Blomberg, Magnus Lundborg, Maréne Landström, Richard Lundmark
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
Endocytosis
clathrin-independent endocytosis
membrane blebbing
membrane tension
GRAF1
cancer invasion
cell migration
ARHGAP26
cell surface dynamics
GRAF1-dependent endocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471731094X

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http://www.sciencedirect.com/science/article/pii/S221112471731094X

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