Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus.

Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus.

BACKGROUND: Independent genome-wide association studies (GWAS) showed an obesogenic effect of two single nucleotide polymorphisms (SNP; rs12970134 and rs17782313) more than 150 kb downstream of the melanocortin 4 receptor gene (MC4R). It is unclear if the SNPs directly influence MC4R function or exp...

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Bibliographic Details
Main Authors: André Scherag, Ivonne Jarick, Jessica Grothe, Heike Biebermann, Susann Scherag, Anna-Lena Volckmar, Carla Ivane Ganz Vogel, Brandon Greene, Johannes Hebebrand, Anke Hinney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2981522?pdf=render

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http://europepmc.org/articles/PMC2981522?pdf=render

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