TLR-2 and MyD88-Dependent Activation of MAPK and STAT Proteins Regulates Proinflammatory Cytokine Response and Immunity to Experimental Trypanosoma congolense Infection

TLR-2 and MyD88-Dependent Activation of MAPK and STAT Proteins Regulates Proinflammatory Cytokine Response and Immunity to Experimental Trypanosoma congolense Infection

It is known that Trypanosoma congolense infection in mice is associated with increased production of proinflammatory cytokines by macrophages and monocytes. However, the intracellular signaling pathways leading to the production of these cytokines still remain unknown. In this paper, we have investi...

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Bibliographic Details
Main Authors: Shiby Kuriakose, Chukwunonso Onyilagha, Rani Singh, Folayemi Olayinka-Adefemi, Ping Jia, Jude E. Uzonna
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
African trypanosome
immune response
proinflammatory cytokines
MAPK
STAT
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02673/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02673/full

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