A new laminopathy caused by an Arg133/Leu mutation in lamin A/C and the effects thereof on adipocyte differentiation and the transcriptome

A new laminopathy caused by an Arg133/Leu mutation in lamin A/C and the effects thereof on adipocyte differentiation and the transcriptome

We report a new laminopathy that includes generalized lipoatrophy, insulin-resistant diabetes, micrognathia and biopsy-proven, focal segmental glomerulosclerosis in a female, caused by a de novo heterozygous mutation R133L in the lamin A/C gene (LMNA). We analysed the nuclear morphology and laminar...

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Bibliographic Details
Main Authors: Zhe Wang, Yueting Dong, Jing Yang, Yingzi He, Xihua Lin, Fang Wu, Hong Li, Fenping Zheng
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Adipocyte
Subjects:
laminopathy
lamin a/c
adipocyte differentiation
insulin resistance
dna damage
Online Access:http://dx.doi.org/10.1080/21623945.2019.1640007

Internet

http://dx.doi.org/10.1080/21623945.2019.1640007

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