CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation.

CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation.

Centralspindlin, a constitutive 2:2 heterotetramer of MKLP1 (a kinesin-6) and the non-motor subunit CYK4, plays important roles in cytokinesis. It is crucial for the formation of central spindle microtubule bundle structure. Its accumulation at the central antiparallel overlap zone is key for recrui...

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Bibliographic Details
Main Authors: Tim Davies, Noriyuki Kodera, Gabriele S Kaminski Schierle, Eric Rees, Miklos Erdelyi, Clemens F Kaminski, Toshio Ando, Masanori Mishima
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1002121

Internet

https://doi.org/10.1371/journal.pbio.1002121

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