P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

Abstract Background Neuronal accumulation of misfolded microtubule-associated protein tau is a hallmark of neuropathology in Alzheimer’s disease, frontotemporal dementia, and other tauopathies, and has been a therapeutic target. Microglia can spread tau pathology by secreting tau-containing exosomes...

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Bibliographic Details
Main Authors: Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Alicia A. Van Enoo, Jianqiao Hu, Seiko Ikezu, Tsuneya Ikezu
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Exosome
Extracellular vesicles
Microglia
Microtubule-associated protein tau
P2X purinoceptor 7
Online Access:http://link.springer.com/article/10.1186/s13024-020-00396-2

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http://link.springer.com/article/10.1186/s13024-020-00396-2

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