Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells.
Pancreatic beta-cell ATP-sensitive potassium (K ATP) channels are critical links between nutrient metabolism and insulin secretion. In humans, reduced or absent beta-cell K ATP channel activity resulting from loss-of-function K ATP mutations induces insulin hypersecretion. Mice with reduced K ATP ch...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-10-01
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| Series: | PLoS Medicine |
| Online Access: | http://europepmc.org/articles/PMC2573909?pdf=render |